Updated! Mounjaro vs. Semaglutide- differences?

I started on compounded Semaglutide first and didn't have much luck with weight loss. I switched to compounded tirzepatide and it was life changing for me. I wanted to lose 30 pounds and lost 35 pounds. I was really worried about putting the weight back on when I came off of it as I couldn't afford to stay on it even at a low dose. So far, I really don't think about food like I used to and have been able to continue with no snacking without much struggle. I've been off about 2 months now and haven't gained, in fact, I've lost another 2 pounds.

I've only been on Mounjaro, but my experience vs those on semaglutide shows me I made the right choice.

I have a friend who has been on both, she said she tolerates the Mounjaro (tirzepatide) much better, much less nausea.

My goal was hoping for 30, aiming for 20. I actually lost 52 lbs and I maintain that on the lowest dose. I'll keep taking it as long as I can afford it because it's been life changing for me.

I'll tell everyone who asks how much is helped with menopause, not just my weight but my whole metabolism/hormonal balance (not that I expect it's that way for everyone, but it's definitely true for me!).

ETA for reference I am 5' 2.5", usually comfortable at a well-muscled 130-140; got up to 167 after menopause kicked in, gaining over 20 lbs in a year; consistently weigh at 115-118 now, eat whatever I want but I just don't eat a lot or crave things usually anymore. I did lose a lot of muscle mass and I've been really lazy about working out, full disclosure.

I was told by my endocrinologist that Mounjaro is the strongest of those type of medications. My sister (diabetic) couldn’t tolerate Mounjaro as it caused the neuropathy pain in her feet to increase. They put her on Trulicity instead.

Well yes, it does dissipate as the week goes on. That's why you take it weekly. I'm not ravenous though--and if I'm on vacation and want to eat out and enjoy all the food, I just skip my shot and resume later.

I have only been on Mounjaro. I have lost 50 lbs so far I still have a lot more to lose. I have to say I have been very lucky as I have not had any bad side effects, I have lost my taste for many foods that I used to like but the only one I really miss is coffee I just can't do it anymore which I guess is good.
My a1c is finally under control and my doctor says by December she will probably take me off all my other type 2 diabetes medication.

I've been on the highest dose of Mounjaro for a good year now for my A1C. I work out 5 days a week and eat pretty healthy. I've lost nothing on it. I've lost 80 pounds on my own so I don't understand why Mounjaro isn't helping me lose more. My habits are the same if not better than before. I have zero side effects. My insurance covers it 100% and I do prefer one shot a week versus Metformin twice per day. It has helped my A1C, but I wish I was having some weight loss as well.

My doctor just put me on this for both high sugars and weight loss.
So far I'm just on the lowest dose.

For those of you who have lost significant weight while using it, can I ask what was the time on that? Did you lose 20lbs in 6 months? Less? more?
I would love to know!

I had to go back and look. I've been on it for one year. I lost 25 lbs in 3 months and the total 52 lbs was within about 8 months. I went from 25 to 50 after the first month, then to 60, then back down to 50, and then back to 25. (This is units, for the compounded med, but it's dosed like Mounjaro not like Zepbound) I do not want to lose any more weight. I keep my dose at the lowest level.

Same for me. It wasn’t a crazy difference, but the effects definitely wane as the week goes by, especially at the beginning! I have always taken mine on Thursday nights. I could push through work on Friday, but this way the full strength was effective over the weekend (when I tended to eat the worst before!) and any potential side effects wouldn’t affect my work, although that didn’t happen.

If you're paying out of pocket for compounded, there are now a ton of options. Here's a few:

Emerge  is very easy to use. You simply email or text with the provider.

Mochi is used by a lot of people. You'd do virtual visits with the doctors.

Lavender Sky is another one I hear about.

I go to a local clinic and they use a compounding pharmacy in Florida to fill the prescriptions. I'm not sure where the FL clinic gets the ingredients, but I can certainly vouch for them working as intended.

Also, my Facebook feed is filled with online options each time I participate in one of these discussions, so you could always check one of the bigger companies
But I'm actually not looking for name brand as it costs more and comes in a one-dose pen. I like being able to choose the dose in case I ever need to titrate up or down. I buy 2 vials at a time to save money.

I used HenryMeds, which had me meet with a doctor in my state via zoom. (I liked having the face-to-face, the first provider I used just did a phone call.)

The prescription was sent to me automatically, every month, from Empower compounding pharmacy in Texas.

I have tried both sema and tirz. Started compounded sema in March of 2023 and did 2 rounds of 3 months with a month off per the med spa. I lost 30 pounds and decided to try tirz from a peptide research online company because I wanted to lose more. It gave me horrible heartburn that I'm still dealing with a bit.
I switched back to sema from the same peptide research company and lost another 10 really slowly and I continue a low dose to maintain. I would be ok with losing maybe 5 more pounds but I'll be happy where I'm at. My doc is over the moon and was ok with when I ordered the compounded version. I'm not sure what she would think of the peptides. I was wary of it but it is what it is, and so much cheaper than even the compounded version.
I just now reached a "normal" bmi weight, this is the smallest I've ever been since 4th grade and I'm 66.

My boss has had great success with Mounjaro and weight loss, decrease in her A1C. She stated that she will not override the lack of desire for food. No longer part of the clean plate club or grabbing the donut or cookie from the break room table because it is there.

Good luck! Hope it is as successful for you.